Core competency is the key to success of the 108 curriculum guideline. Each field/subject has different designs to implementation in the curriculum guideline. This study will analyze and study the optimal teaching, dilemma and improvement strategies for the implementation of core literacy. This research will focus on the natural sciences, and is planned to be supplemented by mathematics and technology that applied in other research projects. Via the analysis of the curriculum documents, consultation and classroom observations, we will establish optimal indicators in the field of natural sciences and propose the use of optimal indicators, methods, difficulties and strategies.